LymphedemaV1, Main, Exploration, bibRecord, 003234

Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis

Identifieur interne : 003234 ( Main/Exploration ); précédent : 003233; suivant : 003235

Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis

Auteurs : Cathy Steel ; Allison Golden ; Joseph Kubofcik ; Nicole Larue ; Tala De Los Santos ; Gonzalo J. Domingo ; Thomas B. Nutman

Source :

Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2013.

RBID : PMC:3754496

Descripteurs français

KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe, Antihelminthiques (usage thérapeutique), Filariose lymphatique (diagnostic), Filariose lymphatique (traitement médicamenteux), Humains, Immunochromatographie (), Immunoglobuline G (sang), Sensibilité et spécificité, Surveillance pharmacologique (), Techniques de laboratoire clinique (), Test ELISA (), Valeur prédictive des tests, Wuchereria bancrofti (immunologie).
MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Wuchereria bancrofti.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Antihelminthiques.
- Animaux, Antigènes d'helminthe, Humains, Immunochromatographie, Sensibilité et spécificité, Surveillance pharmacologique, Techniques de laboratoire clinique, Test ELISA, Valeur prédictive des tests.

English descriptors

KwdEn :
- Animals, Anthelmintics (therapeutic use), Antibodies, Helminth (blood), Antigens, Helminth, Clinical Laboratory Techniques (methods), Drug Monitoring (methods), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Enzyme-Linked Immunosorbent Assay (methods), Humans, Immunochromatography (methods), Immunoglobulin G (blood), Predictive Value of Tests, Sensitivity and Specificity, Wuchereria bancrofti (immunology).
MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , therapeutic use : Anthelmintics.
- diagnosis : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- methods : Clinical Laboratory Techniques, Drug Monitoring, Enzyme-Linked Immunosorbent Assay, Immunochromatography.
- Animals, Antigens, Helminth, Humans, Predictive Value of Tests, Sensitivity and Specificity.

Abstract

The Global Programme to Eliminate Lymphatic Filariasis has an urgent need for rapid assays to detect ongoing transmission of lymphatic filariasis (LF) following multiple rounds of mass drug administration (MDA). Current WHO guidelines support using the antigen card immunochromatographic test (ICT), which detects active filarial infection but does not detect early exposure to LF. Recent studies found that antibody-based assays better serve this function. In the present study, two tests, a rapid IgG4 enzyme-linked immunosorbent assay (ELISA) and a lateral-flow strip immunoassay, were developed based on the highly sensitive and specific Wuchereria bancrofti antigen Wb123. A comparison of W. bancrofti-infected and -uninfected patients (with or without other helminth infections) demonstrated that both tests had high sensitivities and specificities (93 and 97% [ELISA] and 92 and 96% [strips], respectively). When the W. bancrofti-uninfected group was separated into those with other filarial/helminth infections (i.e., onchocerciasis, loiasis, and strongyloidiasis) and those who were parasite uninfected, the specificities of the assays varied between 91 and 100%. In addition, the geometric mean response by ELISA of W. bancrofti-infected patients was significantly higher than the response of those without W. bancrofti infection (P < 0.0001). Furthermore, the Wb123 ELISA and the lateral-flow strips had high positive and negative predictive values, giving valuable information on the size of survey population needed to be reasonably certain whether or not transmission is ongoing. These highly sensitive and specific IgG4 tests to the W. bancrofti Wb123 protein give every indication that they will serve as useful tools for post-MDA monitoring.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754496

DOI: 10.1128/CVI.00252-13
PubMed: 23740923
PubMed Central: 3754496

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The Global Programme to Eliminate Lymphatic Filariasis has an urgent need for rapid assays to detect ongoing transmission of lymphatic filariasis (LF) following multiple rounds of mass drug administration (MDA). Current WHO guidelines support using the antigen card immunochromatographic test (ICT), which detects active filarial infection but does not detect early exposure to LF. Recent studies found that antibody-based assays better serve this function. In the present study, two tests, a rapid IgG4 enzyme-linked immunosorbent assay (ELISA) and a lateral-flow strip immunoassay, were developed based on the highly sensitive and specific <named-content content-type="genus-species">Wuchereria bancrofti</named-content>
 antigen Wb123. A comparison of <named-content content-type="genus-species">W. bancrofti</named-content>
-infected and -uninfected patients (with or without other helminth infections) demonstrated that both tests had high sensitivities and specificities (93 and 97% [ELISA] and 92 and 96% [strips], respectively). When the <named-content content-type="genus-species">W. bancrofti</named-content>
-uninfected group was separated into those with other filarial/helminth infections (i.e., onchocerciasis, loiasis, and strongyloidiasis) and those who were parasite uninfected, the specificities of the assays varied between 91 and 100%. In addition, the geometric mean response by ELISA of <named-content content-type="genus-species">W. bancrofti</named-content>
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Serveur d'exploration sur le lymphœdème

Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis

Rapid Wuchereria bancrofti-Specific Antigen Wb123-Based IgG4 Immunoassays as Tools for Surveillance following Mass Drug Administration Programs on Lymphatic Filariasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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